IN-FRAME AMBER STOP CODON REPLACEMENT MUTAGENESIS FOR THE DIRECTED EVOLUTION OF PROTEINS CONTAINING NON-CANONICAL AMINO ACIDS: IDENTIFICATION OF RESIDUES OPEN TO BIO-ORTHOGONAL MODIFICATION.

Expanded genetic code approaches are a powerful means to add new and useful chemistry to proteins at defined residues positions.One such use is the introduction of non-biological reactive chemical Soldering Tools handles for site-specific biocompatible orthogonal conjugation of proteins.Due to our currently limited information on the impact of non-

Histological images present high appearance variability due to inconsistent latent parameters related to the preparation and scanning procedure of histological slides, as well as the inherent biological variability of tissues.Machine-learning models are trained with images from a limited set of domains, and are expected to generalize to images from

The accuracy of seismic Mounting Plate demand models in seismic vulnerability analysis of structures or components mainly depends on the seismic intensity measures (IMs) and engineering demand parameters (EDPs).This paper proposes a novel method to obtain the optimal seismic demand model for the seismic vulnerability analysis of bridges.The method

Abstract Background The mechanisms by which glia respond to viral central nervous system (CNS) pathogens are now becoming apparent with the demonstration that microglia and astrocytes express an array of pattern recognition receptors that include intracellular RNA and DNA sensors.We have previously demonstrated that glia express Z-DNA binding prote